New Tools for Ubiquitin Signaling
نویسندگان
چکیده
منابع مشابه
New tools for ubiquitin signaling.
Protein ubiquitination is rapidly emerging as a key regulatory mechanism of many cellular processes. Important roles in proteasomal degradation are contrasted by various non-degradative functions of ubiquitin in intracellular trafficking, signal transduction and the DNA damage response. This versatility arises from eight structurally and functionally distinct polyubiquitin chains that co-exist ...
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The reversible post-translational modification of proteins by ubiquitin and ubiquitin-like proteins regulates almost all cellular processes, by affecting protein degradation, localization, and complex formation. Deubiquitinases (DUBs) are proteases that remove ubiquitin modifications or cleave ubiquitin chains. Most DUBs are cysteine proteases, which makes them well suited for study by activity...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2012
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2012.02.032